News & Press
Abbisko Therapeutics Completes Dosing of the First Subject in the Dose Expansion Part of Phase I Trial for CSF-1R Inhibitor ABSK021
17 November, 2021, Shanghai – Abbisko Therapeutics Co., Ltd. (“Abbisko Therapeutics” hereafter) today announced dosing of the first patient in the phase I clinical trial dose expansion part in US for ABSK021, an oral small molecule CSF-1R inhibitor. The purpose of dose expansion is to access the safety, tolerability, and preliminary anti-tumor activity of ABSK021 in patients with multiple solid tumors.
ABSK021 is a novel, orally available, highly selective, and highly potent small molecule inhibitor of CSF-1R. It has been previously shown by several clinical studies that blocking the CSF-1R signaling pathway could effectively modulate tumor microenvironment, relieve tumor immunosuppression, and synergize with other anti-cancer therapies such as immune checkpoint inhibitors to achieve tumor inhibition. Several clinical studies have also demonstrated that inhibition of CSF-1R activity could be used to treat tenosynovial giant cell tumor (TGCT), and to treat a variety of malignancies through combination with immuno-oncology and/or other therapeutic agents. As of the date of this article, no CSF-1R inhibitor has been approved in China.
ABSK021 is the first selective CSF-1R inhibitor independently developed by a Chinese company that has advanced into human clinical trial. A phase Ia dose escalation study has been completed in the US and demonstrated excellent PK/PD and safety profile of ABSK021 in human. In parallel, we have initiated ABSK021 phase I trial in China and have recruited several solid tumor patients including lung cancer patients.
The forward-looking statements made in this article relate only to the events or information as of the date on which the statements are made in this article. Except as required by law, we undertake no obligation to update or revise publicly any forward-looking statements, whether as a result of new information, future events or otherwise, after the date on which the statements are made or to reflect the occurrence of unanticipated events. You should read this article completely and with the understanding that our actual future results or performance may be materially different from what we expect. In this article, statements of, or references to, our intentions or those of any of our Directors or our Company are made as of the date of this article. Any of these intentions may alter in light of future development.